Abstract
Background: Chronic anal fissure is a common debilitating condition characterized by a tear in the lining of the anal canal, leading to severe pain, discomfort, and bleeding during bowel movements. The treatment modalities for this condition have been explored to alleviate symptoms and promote healing.
The aim of this study was to compare the efficacy, safety, and outcomes of combined topical treatment versus surgical treatment in the management of chronic anal Fissure.
Methods: This study was designed as a prospective, randomized controlled trial. Patients were randomly assigned to either the combined treatment group or the surgical treatment group using computer-generated randomization. Patients in both treatment groups underwent lateral internal sphincterotomy (LIS) under general or local anesthesia, performed by experienced colorectal surgeons.
Results: A total of 100 patients were included in the study, with 50 patients in each treatment group. The combined treatment groups exhibited a slightly higher mean pain relief score compared to the topical group (9.21.0 vs. 8.51.2, respectively). Healing Rate: The healing rate was higher in the surgical group (95% versus 75%, respectively), and the complication rate was slightly higher in both groups. Overall, patients in both treatments reported high levels of satisfaction with their treatment outcomes.
Conclusions: Both combined treatment and surgical treatment have demonstrated efficacious effects in promoting fission healing, with surgical intervention offering superior outcomes in terms of healing rates. However, further research and clinical trials are needed to refine treatment algorithms and improve patient outcomes. Future research with larger cohorts and extended follow-up periods is warranted to validate our findings and further refine treatment protocols.