A REVIEW ON ORAL LIPOSPHERE OF CANDESARTAN CILEXETIL

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Madhukanwar Rathore Dr. Manish Kumar Gupta Vijay Sharma

Abstract

Lipospheres are amongst the promising particulate drug delivery systems for improving dissolution rate of water insoluble drugs that were initially reported as a particulate dispersion of solid spherical particles between 0.2-100μm in diameter consisting of solid hydrophobic fat core such as triglycerides or fatty acids derivatives, stabilized by monolayer of phospholipids. The lipospheres are distinct from microspheres of uniformly dispersed material in homogenous polymer since they consist of two layers, the inner solid particle that contains the entrapped drug with phospholipids outer layer. Many of the drug substances are characterized by poor aqueous solubility, which cause many formulation problems. Beside the use of so-solvents, drug complexation and solubilization in surfactant micelles, incorporation in colloidal carrier system represents an alternative way to render poorly water soluble drug applicable for effective therapy.

Keywords:-Lipospheres, surfactant, micelles,solubilization, Polymer Lipospheres

Article Details

How to Cite
Rathore, M., Gupta, D. M. K., & Sharma, V. (2018). A REVIEW ON ORAL LIPOSPHERE OF CANDESARTAN CILEXETIL. International Journal of Pharmaceutical and Biological Science Archive, 6(01). Retrieved from http://ijpba.in/index.php/ijpba/article/view/77
Section
Review Article