A REVIEW: FORMULATE AND EVALUATE DISPERSIBLE TABLET OF ACECLOFENAC FOR ENHANCEMENT OF BIOAVAILABILITY

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SatyaPrakash Chand Kaushik Priti Luhadia Vijay Sharma

Abstract

Pharmaceutical companies are focusing of new drug delivery systems for existing drug with an improved efficacy and bioavailability1. The oral route of administration is the most important method of administering drugs for systemic effects. Drug absorption is determined by physicochemical properties of drugs, their formulations, and routes of administration. When drug is administered orally. Dispersible tablets are uncoated tablets intended to be dispersed in water before administration giving a homogeneous dispersion. Typically a dispersible tablet is dispersed in about 5-15 ml of water and the resulting dispersion is administered to the patient. Aceclofenac is a non-steroidal agent with analgesic and anti-inflammatory properties; it provides symptomatic relief in a variety of painful conditions.
Aceclofenac may increase plasma concentrations of lithium, digoxin and methotrexate increase the activity of anticoagulant inhibits the activity of diuretics, enhance cyclosporin nephrotoxicity and precipitate convulsions when co-administered with quinolone antibiotics.
KEY WORDS: DispersibleTablet, Aceclofenac Anti-inflammatory, Wet granulation.

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How to Cite
Kaushik, S. C., Luhadia, P., & Sharma, V. (2018). A REVIEW: FORMULATE AND EVALUATE DISPERSIBLE TABLET OF ACECLOFENAC FOR ENHANCEMENT OF BIOAVAILABILITY. International Journal of Pharmaceutical and Biological Science Archive, 6(01). Retrieved from http://ijpba.in/index.php/ijpba/article/view/83
Section
Review Article